Cell cycle machinery in mouse development and in cancer

Piotr SiciƄski

Cyclins and their associated cyclin-dependent kinases (CDKs) represent the ultimate recipients of the mitogenic and oncogenic signals. The cyclin D1 gene represents the second most frequently amplified locus in the human cancer genome. Also, other cyclins which operate during the G1 phase of the cell cycle (D-type and E-type cyclins) are frequently overexpressed in human cancers. In my talk, I will discuss our recent genome- and proteome-wide screens using genetically engineered mice, as well as using human cancer cells. The goal of these screens is to elucidate the full repertoire of cyclin-CDK function in normal development and in cancer formation.